To treat cancer effectively, Zong Lab has devoted great efforts to molecularly targeted therapy. While there have been many examples of success, cancer cells often develop drug resistance to evade therapy. To increase the efficacy of cancer therapy, Zong Lab–a part of the Department of Microbiology, Immunology and Cancer Biology (MIC)— uses a mouse genetic mosaic model termed MADM to study how tumor cells attack in vivo from the tumor-initiating stage and at the single-cell resolution.