Year 2 Supplement: Kevin Janes PhD, UVa Department of Biomedical Engineering in collaboration with John Lowengrub, UC Irvine Department of Mathematics. National Cancer Institute (#3-U54-CA274499-02S1; PI: Janes -UVA) 9/1/2023 – 8/31/2024) “Open phase-separation models for cancer systems biology”
Investigators
Research
Separation of soft biological phases is observed at multiple length scales in cancer. It is critical to model the creation and dynamics of phase-separated interfaces toward understanding what systems-level properties are enabled. The SASCO CSBC Center at the University of Virginia (U54-CA274499) has a significant interest in building predictive models of liquid-liquid demixing for the chromosome passenger complex, a sensor and repair enzyme for improper microtubule attachments during metaphase. New collaborators at the University of California, Irvine are experts in nonlinear numerical methods for chemical-physics models of phase separation. We propose to work together and build extensible numerical solvers of two-phase dynamics and share them openly to the biomedical community through global repositories and the NIH-supported research resource, VCell.
