The organelles of cancer cells must adapt to oncogenic stress for tumors to initiate and progress, but there is little to no systems-level understanding of how such adaptations occur. The Systems Analysis of Stress-adapted Cancer Organelles (SASCO) Center at the University of Virginia is addressing this challenge by mechanistic modeling of organellar processes that iterates with quantitative experiments in disease-relevant cell cultures and primary tumors. The Center brings together investigators with primary and collaborative track records in cancer biology, systems biology, genetically engineered mouse models of cancer, and clinical practice.

Medicine in Motion Article

Next SASCO Seminar  May 19, 2026 3-4:30pm MEB 1110 (Learning Studio)

Daniel Phipps (Project 2) “Ras-driven Drp1 activity maintains mitochondrial genome integrity to promote tumor cell fitness in colorectal cancer.”

Max Mendrzycki (Project 3)”Utilizing Base Editing to Understand Resistance Mechanisms to RTK-targeted Therapies”

Allison May (CCP final update) “Mapping epithelial to mesenchymal transition states in sarcomatoid renal cell carcinoma”

ZOOM

(Meeting ID: 944 2797 6653  Pass: 1005)