The organelles of cancer cells must adapt to oncogenic stress for tumors to initiate and progress, but there is little to no systems-level understanding of how such adaptations occur. The Systems Analysis of Stress-adapted Cancer Organelles (SASCO) Center at the University of Virginia is addressing this challenge by mechanistic modeling of organellar processes that iterates with quantitative experiments in disease-relevant cell cultures and primary tumors. The Center brings together investigators with primary and collaborative track records in cancer biology, systems biology, genetically engineered mouse models of cancer, and clinical practice.
Our work is made possible by funding from the Cancer Systems Biology Consortium.
A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancer.
View ORCID ProfileJianhao Zeng, Shambhavi Singh, Ying Jiang, Eli Casarez, Kristen A. Atkins, Kevin A. Janes, View ORCID ProfileHui Zong.
bioRxiv. 2023; .
Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state.
Lixin Wang, B. Bishal Paudel, R. Anthony McKnight, Kevin A. Janes.
Nature Communications. 2023; 14(1):2110.
Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma.
Dane T. Sessions, Kee-Beom Kim, Jennifer A. Kashatus, Nikolas Churchill, Kwon-Sik Park, Marty W. Mayo, Hiromi Sesaki, David F. Kashatus.
Cell Reports. 2022; 41(11):111818.
View ORCID ProfileJianhao Zeng, Shambhavi Singh, Ying Jiang, Eli Casarez, Kristen A. Atkins, Kevin A. Janes, View ORCID ProfileHui Zong.
bioRxiv. 2023; .
Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state.
Lixin Wang, B. Bishal Paudel, R. Anthony McKnight, Kevin A. Janes.
Nature Communications. 2023; 14(1):2110.
Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma.
Dane T. Sessions, Kee-Beom Kim, Jennifer A. Kashatus, Nikolas Churchill, Kwon-Sik Park, Marty W. Mayo, Hiromi Sesaki, David F. Kashatus.
Cell Reports. 2022; 41(11):111818.