The organelles of cancer cells must adapt to oncogenic stress for tumors to initiate and progress, but there is little to no systems-level understanding of how such adaptations occur. The Systems Analysis of Stress-adapted Cancer Organelles (SASCO) Center at the University of Virginia is addressing this challenge by mechanistic modeling of organellar processes that iterates with quantitative experiments in disease-relevant cell cultures and primary tumors. The Center brings together investigators with primary and collaborative track records in cancer biology, systems biology, genetically engineered mouse models of cancer, and clinical practice.
Our work is made possible by funding from the Cancer Systems Biology Consortium.
Proteome-wide copy-number estimation from transcriptomics.
Andrew J Sweatt, Cameron D Griffiths, Sarah M Groves, B Bishal Paudel, Lixin Wang, David F Kashatus, and Kevin A Janes.
Mol Syst Biol. 2024; online ahead of print.
Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations.
Cara Abecunas, Audrey D Kidd, Ying Jiang, Hui Zong, Mohammad Fallahi-Sichani.
Cell Rep.. 2024; Sep 20;43(10):114775.
Protocol for iterative indirect immunofluorescence imaging in cultured cells, tissue sections, and metaphase chromosome spreads.
Hsu J, Nguyen KT, Bujnowska M, Janes KA, Fallahi-Sichani M.
STAR Protoc. 2024; 5, 103190.
Andrew J Sweatt, Cameron D Griffiths, Sarah M Groves, B Bishal Paudel, Lixin Wang, David F Kashatus, and Kevin A Janes.
Mol Syst Biol. 2024; online ahead of print.
Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations.
Cara Abecunas, Audrey D Kidd, Ying Jiang, Hui Zong, Mohammad Fallahi-Sichani.
Cell Rep.. 2024; Sep 20;43(10):114775.
Protocol for iterative indirect immunofluorescence imaging in cultured cells, tissue sections, and metaphase chromosome spreads.
Hsu J, Nguyen KT, Bujnowska M, Janes KA, Fallahi-Sichani M.
STAR Protoc. 2024; 5, 103190.