Project 1. Robust-to-fragile transitions of a phase-separated mitotic organelle in triple-negative breast cancer
This project examines phase separation-mediated organellogenesis of the chromosome passenger complex during metaphase in a breast cancer subtype that is prone to aneuploidy.
Project 2. A systems-metabolism approach to identify mitochondria-dependent vulnerabilities in colorectal cancer
This project investigates the metabolic-network consequences of mitochondrial fragmentation in RAS-mediated colorectal cancer and the associated microbiome.
Project 3. EGFR signaling network adaptations to overcome RAS-induced membrane stress in glioblastoma
This project evaluates the role of mutant EGFRvIII in alleviating cell death by methuosis (excessive macropinocytosis) in glioblastomas with hyperactivation of RAS.