To treat cancer effectively, Zong Lab has devoted great efforts to molecularly targeted therapy. While there have been many examples of success, cancer cells often develop drug resistance to evade therapy. To increase the efficacy of cancer therapy, Zong Lab–a part of the Department of Microbiology, Immunology and Cancer Biology (MIC)— uses a mouse genetic mosaic model termed MADM to study how tumor cells attack in vivo from the tumor-initiating stage and at the single-cell resolution.
Our overriding interest is tackling the challenge of tyrosine phosphorylation, and we cross disciplines as necessary to achieve this goal.
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Network modeling of biological systems to predict drug targets and understand mechanisms of disease.
The Kashatus Lab is interested in the regulation of mitochondrial dynamics and how alterations in mitochondrial fission and fusion affect basic cellular physiology. We explore these questions using a wide variety of approaches, from cell biology to mouse genetics to bioinformatics with the ultimate goal of identifying how mitochondrial dynamics and metabolic function impact the progression of cancer and other diseases.
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